Comment: A critical takeaway from this meta-analysis is the comparable safety profile of DTE. The data indicates no significant negative impact on key outcomes such as heart rate or lipid profiles when compared to standard T4 monotherapy. Beyond its safety, a key potential benefit highlighted is its effect on reverse T3 (rT3). Treatment with DTE […]

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Comment: This is yet another high-quality, randomized controlled trial that undermines the long-standing bias against Desiccated Thyroid Extract (DTE). The overall finding is clear: for the average hypothyroid patient, DTE is non-inferior—meaning equivalent—to synthetic levothyroxine (LT4) when it comes to quality of life, memory, and depressive symptoms. The most compelling takeaway (although a post hoc […]

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Comment: This is a fascinating retrospective study that directly challenges a core assumption in conventional endocrinology. The prevailing dogma is that synthetic levothyroxine provides superior TSH stability, with desiccated thyroid extract (DTE) often dismissed as an inconsistent or unstable option. However, this real-world data demonstrates that for the primary clinical goal—keeping a patient’s TSH within […]

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