Comment: Another in a line of studies showing that our concept of cholesterol is wrong when it comes to the outcomes that matter. This one is particularly interesting as it breaks it down by age, showing that as we get older, higher cholesterol becomes more protective. Summary: Based on this large observational study, the health […]
Comment: Another in a series of studies that contradicts the dogma that lower cholesterol is better. Although the authors calculated cut off points, using the spline graphs you can see that cholesterol up to about the 230 range is lowest risk of overall deaths and even 300 is better than 180. For cancer you’re safer and […]
Comment: comment here Summary: Clinical Bottom Line This large-scale, pooled analysis of observational studies provides moderate-quality evidence that higher levels of omega-3 fatty acids from habitual dietary intake are not associated with an increased risk of atrial fibrillation (AF) and may, in fact, be modestly protective. Specifically, while eicosapentaenoic acid (EPA) levels showed no association, […]
Comment: Summary: Clinical Bottom Line This review presents a compelling “double-edged sword” hypothesis for the effect of omega-3 fatty acids on the risk of atrial fibrillation (AF). The key takeaway is that the dose and source matter. Low-to-moderate dietary intake of omega-3s from fish (around 600–700 mg/day) appears to be associated with a reduced […]
Comment: Although this doesn’t negate the potential of increased risk of atrial fibrillation seen in other studies, a lower rate of death seems more important. Summary: Clinical Bottom Line This large cohort study shows a modest association between habitual fish oil use and a lower risk of all-cause mortality. However, it is not possible to […]
Comment: This article made a big splash in the media and led to a lot of questions from patients about the safety of taking fish oil supplements. Understanding that this is an observational study, it does show an increase in atrial fibrillation in people who consume fish oil supplements. What’s intriguing, and makes me more […]
Comment: Although there are some potential benefits to hormone replacement therapy, there are significant risks associated as well. This study is another one that shows significant cardiovascular harm, with increases in stroke and thromboembolism.` Summary: Clinical Bottom Line This high-certainty meta-analysis demonstrates that for the general postmenopausal population, menopause hormone therapy (MHT) is […]
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Comment I’ve been using a basic rule of thumb – D3 – D2 = real vitamin D This study doesn’t exactly say that, but does give me a basis for my general statement that D2 may be worse than no D at all as it negatively impacts D3 status. Summary Title of the Article: […]
Comment: Another study showing that animal protein intake does not increase death rates. In fact, this study links higher animal protein intake to a reduced risk of cancer, albeit small. Clinical Bottom Line This large cohort study found no association between the usual intake of either animal or plant protein and the risk of […]
