Comment: This is yet another high-quality, randomized controlled trial that undermines the long-standing bias against Desiccated Thyroid Extract (DTE). The overall finding is clear: for the average hypothyroid patient, DTE is non-inferior—meaning equivalent—to synthetic levothyroxine (LT4) when it comes to quality of life, memory, and depressive symptoms. The most compelling takeaway (although a post hoc […]

Read More »

Comment: This is a fascinating retrospective study that directly challenges a core assumption in conventional endocrinology. The prevailing dogma is that synthetic levothyroxine provides superior TSH stability, with desiccated thyroid extract (DTE) often dismissed as an inconsistent or unstable option. However, this real-world data demonstrates that for the primary clinical goal—keeping a patient’s TSH within […]

Read More »

Comment: This is a well-designed, double-blind, crossover trial putting DTE and levothyroxine head-to-head. The top line findings, that the primary outcomes for the whole group weren’t different, is a great start for substantiating that at the least Natural Desiccated Thyroid is equivalent to levothyroxine. However the secondary findings, although in a sub-group population are very […]

Read More »