Gastrointestinal Health – NatWonk – Dr Bier’s Research Reviews

Critical appraisal of the SIBO hypothesis and breath testing: A clinical practice update endorsed by the European society of neurogastroenterology and motility (ESNM) and the American neurogastroenterology and motility society (ANMS)

February 14, 2026

| Gastrointestinal Health, Labs & Statistics

Comment: A central issue with the concept of SIB is the conflict between the biochemical allure of a bacterial explanation for complex symptoms and the physiological reality that our diagnostic tools are structurally incapable of distinguishing between overgrowth and simple transit speed. This clinical practice update from the ESNM and ANMS reveals that the Lactulose […]

Complications of colonoscopy

February 14, 2026

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| Gastrointestinal Health

Comment: A fundamental conflict exists between the perception of colonoscopy as a “perfectly safe” routine screening and the dramatic iatrogenic escalation that occurs once a procedure becomes therapeutic. While the corrected data for diagnostic perforation is a negligible 0.03%, this “safety halo” disappears the moment a polyp is identified for removal. The human clinical data […]

Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans: cohort study

December 22, 2025

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| Gastrointestinal Health, Longevity & Mortality, Medications - General Pharmaceuticals

Comment: A hazard ratio of 1.17 for all-cause mortality is a statistic that shouldn’t be ignored, but unfortunately is. It translates to 45 excess deaths for every 1,000 patients treated. But the most concerning aspect of this data is the graded relationship: the longer the exposure, the higher the risk of death. This dose-response curve […]