Comment: I always prioritize all-cause mortality data over mechanism, and the hypothesis that sun exposure is negative is at this point dogmatic. This 2018 review is another showing the prevailing clinical mandate for UV avoidance conflicts with the documented reality that sun avoidance is a negative factor for human longevity. The Melanoma in Southern Sweden […]
Comment: This genotype study once again contradicts the prevailing narrative that meat is a universal cognitive toxin, and even it’s negative impact on all-cause mortality. The findings from this 15-year Swedish cohort are unequivocal. There is absolutely no genetic subgroup in this study where higher total meat consumption increased the risk of dementia. In fact, […]
Comment: There is an assumption that specific routes of hormone therapy (MHT) offer a safe harbor from cardiovascular risk, yet this systematic review of over 5.5 million women identifies a profound disconnect between biochemical promise and systemic biological reality. While early initiation is frequently justified by observational data, we should recognize that these perceived benefits […]
Comment: A more recent study, this one was in women and showed that nuts and this time seeds are perfectly safe for diverticulitis. Corn actually decreased the risk. Summary: 🎯 Clinical Bottom Line This large prospective cohort study provides compelling evidence to refute the historical dogma that women should avoid “particulate” foods—specifically nuts, seeds, corn, […]
Comment: Not only do nuts not increase incidence, but they actually decrease the incidence. Another example of ‘logical’ thinking that was wrong on testing, but still endures. One of my favorite quotes ever, from the lead researcher, in that it underlines so much of medical thinking:“It is not exactly clear where this idea came from […]
Comment: This one’s a bit of a favorite, as I don’t think anyone who measures vitamin D serum levels in clinical practice believes the IOM suggested dose could possibly be accurate. Here the authors point out a statistical mistake that was made and reassesses the same data to come to extrapolate to a far higher […]
Comment: This is a graph that I keep close at hand as I share it with patients very frequently. It shows how diverse the requirements are to achieve adequate serum vitamin D levels, and how the actual supplementation level to get most people into target range is far higher than the IOM recommendations, which were […]
Comment: A critical takeaway from this real-world data is the apparent lack of protection for oncology patients. The finding for the immunocompromised subgroup—which includes many patients with active cancer or on immunosuppressive therapy—is stark. A vaccine effectiveness of 30% that is not statistically significant (95% CI, -9% to 55%) means we cannot conclude there is […]
Comment: This is a crucial systematic review that directly addresses a common clinical misconception. For years, the standard advice has been to stop fish oil before surgery due to a theoretical risk of bleeding based on its known effects on platelet aggregation. What this review clearly demonstrates is that this theoretical risk does not […]
Comment: This study is a critical piece of evidence that directly challenges a long-standing piece of medical dogma. For decades, we have routinely advised patients to stop fish oil supplements before surgery, fearing an increased risk of bleeding. This was solely based on hypothesis. This robust analysis of the OPERA trial not only debunks that […]
