Longevity & Mortality – NatWonk – Dr Bier's Research Reviews

HbA1c and Risks of All-Cause and Cause-Specific Death in Subjects without Known Diabetes: A Dose-Response Meta-Analysis of Prospective Cohort Studies

February 8, 2026

| Cancer, Longevity & Mortality, Metabolic Health

Comment: The traditional clinical focus on hemoglobin A1c (HbA1c) often assumes a benign risk profile until the formal 6.5% diabetic threshold is reached, which is something we in the Naturopathic world know to not be true. This dose-response meta-analysis dismantles that assumption, identifying that every 1% increase in HbA1c is associated with a 3% increase […]

The association of skipping breakfast with cancer-related and all-cause mortality in a national cohort of United States adults

January 25, 2026

| No Comments

| Cancer, Diet & Nutrition, Longevity & Mortality

Comment: The current narrative surrounding Time-Restricted Eating (TRE) often relies on short-term metabolic markers or mechanistic theories to justify skipping the morning meal, but this massive prospective cohort study forces us to confront the hierarchy of clinical evidence: hard mortality endpoints consistently trump biochemical plausibility. In a nationally representative sample of over 7,000 adults followed […]

A National Study Exploring the Association between Fasting Duration and Mortality among the Elderly

January 25, 2026

| No Comments

| Diet & Nutrition, Longevity & Mortality

Comment: This is another large-scale analysis to flag a mortality signal, giving sufficient reason to move the discussion from a “statistical fluke” to a “clear clinical pattern.” There is often a linear assumption—that if a 12-hour fast is good, 16 hours must be better. However, this US-based cohort study of over 10,000 elderly adults forces […]

The association between skipping breakfast and cardiovascular disease: a meta analysis

January 24, 2026

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| Cardiovascular Health, Diet & Nutrition, Longevity & Mortality

Comment: It is always important the acknowledge the risks in observational studies, however when the results keep coming back the same, it is important to pay attention. The Core Tension in the current discourse on metabolic health is the friction between the popularized biochemical “panacea” of intermittent fasting and the sobering mortality signals emerging from […]

Meal Skipping and Shorter Meal Intervals Are Associated with Increased Risk of All-Cause and Cardiovascular Disease Mortality among US Adults

January 24, 2026

| No Comments

| Cardiovascular Health, Diet & Nutrition, Longevity & Mortality

Comment: There is a conflict between the biochemical promise of Time-Restricted Eating (TRE) and the hard reality of epidemiological survival data. Protocols like “One Meal a Day” (OMAD) are promoted for their theoretical impact on autophagy and insulin sensitivity, yet frequently ignores the most important metric: Overall Survival. While short-term mechanistic studies suggest metabolic benefit, […]

Breakfast skipping and risk of all-cause, cardiovascular and cancer mortality among adults: a systematic review and meta-analysis of prospective cohort studies

January 24, 2026

| No Comments

| Cancer, Cardiovascular Health, Diet & Nutrition, Longevity & Mortality

Comment: The data presented in this systematic review and meta-analysis of 242,095 participants reveals a stark collision between the biochemical promise of intermittent fasting (IF) and the hard reality of epidemiological survival. While IF is frequently promoted as a metabolic panacea—citing mechanisms like autophagy and improved insulin sensitivity—these theories often ignore the hierarchy of harm: […]

Vitamin B12 supports skeletal muscle oxidative phosphorylation capacity in male mice

January 23, 2026

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| Longevity & Mortality

Comment: Starting with the clear caveats that this is a preclinical mouse study and a pre-print (has not undergone peer review yet), this is still a fascinating study. We typically categorize Vitamin B12 deficiency as a hematologic or neurological issue, often overlooking or underestimating its structural role in muscle bioenergetics. This study brings the musculoskeletal […]

Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans: cohort study

December 22, 2025

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| Gastrointestinal Health, Longevity & Mortality, Medications - General Pharmaceuticals

Comment: A hazard ratio of 1.17 for all-cause mortality is a statistic that shouldn’t be ignored, but unfortunately is. It translates to 45 excess deaths for every 1,000 patients treated. But the most concerning aspect of this data is the graded relationship: the longer the exposure, the higher the risk of death. This dose-response curve […]

Coffee drinking timing and mortality in US adults

December 21, 2025

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| Diet & Nutrition, Longevity & Mortality

🍵Comment: Another study dismantling the dogma that coffee is ‘bad for you.’ On the contrary, the data here shows that ‘morning-type’ drinkers enjoy a statistically significant reduction in both all-cause and cardiovascular mortality compared to non-drinkers. These findings also introduce a vital caveat: the circadian context. The fact that heavy consumption is protective only in […]

Evaluating the Association Between Low-Density Lipoprotein Cholesterol Reduction and Relative and Absolute Effects of Statin Treatment

October 21, 2025

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| Cardiovascular Health, Longevity & Mortality

Meta-analyses showed reductions in the absolute risk of 0.8% (95% CI, 0.4%-1.2%) for all-cause mortality, 1.3% (95% CI, 0.9%-1.7%) for myocardial infarction, and 0.4% (95% CI, 0.2%-0.6%) for stroke in those randomized to treatment with statins,