📝Comment: This meta-analysis represents the highest level of evidence for a prognostic biomarker, using Individual-Participant-Data (IPD) analysis across 15 high-quality prospective cohorts. While the absolute increase in risk prediction (C-index) is modest, high-sensitivity troponins are an independent prognostic factor for cardiovascular disease that provide greater predictive gains than traditional inflammatory markers like C-reactive protein (CRP), […]

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Comment: Although we are all used to seeing troponin used to rule in or out a heart attack, this study shows it can be used for prognostic chronic risk stratification. It shows there is a population of older, asymptomatic people who, despite having no history of MI or overt CVD, are walking around with a […]

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