Category: Longevity & Mortality

Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review

October 20, 2025
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| Cardiovascular Health, Longevity & Mortality

Comment: The traditional cardiological focus on lowering LDL-C in the elderly rests on a foundation of biochemical plausibility that is increasingly dismantled by actual survival data. This systematic review identified a critical physiological disconnect: for those over age 60, high LDL-C is not a mortality stressor but is actually associated with a longer lifespan. In […]

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Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults

October 19, 2025
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| Cardiovascular Health, Longevity & Mortality

Comment: Another in a line of studies showing that our concept of cholesterol is wrong when it comes to the outcomes that matter. This one is particularly interesting as it breaks it down by age, showing that as we get older, higher cholesterol becomes more protective. The Wonk Debate – Audio Critique & Clinical Commentary: […]

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Associations of habitual fish oil supplementation with cardiovascular outcomes and all cause mortality: evidence from a large population based cohort study

October 18, 2025
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| Cardiovascular Health, Longevity & Mortality

Comment: Although this doesn’t negate the potential of increased risk of atrial fibrillation seen in other studies, a lower rate of death seems more important. Summary: Clinical Bottom Line This large cohort study shows a modest association between habitual fish oil use and a lower risk of all-cause mortality. However, it is not possible to […]

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Animal and plant protein usual intakes are not adversely associated with all-cause, cardiovascular disease-, or cancer-related mortality risk: an NHANES III analysis

September 20, 2025
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| Cancer, Cardiovascular Health, Diet & Nutrition, Longevity & Mortality

Comment: Another study showing that animal protein intake does not increase death rates. In fact, this study links higher animal protein intake to a reduced risk of cancer, albeit small. This study was designed specifically to revisit the controversial 2014 Levine findings that suggested a four-fold cancer risk from animal protein. By applying more sophisticated statistical […]

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