Comment: I have used PRP for thumb joint pain and seen it been very helpful. This trial paints a very hopeful picture for the use of PRP for thumb CMC OA treatments. While we definitely need larger controlled trials to confirm these results, the initial data—specifically the high rate of moderate-to-excellent improvement—indicates that PRP could […]
Comment: This study reinforces a critical physiological reality often obscured by the aggressive ‘lower is better’ paradigm for lipids. While the cardiovascular benefits of managing dyslipidemia are well-established, we frequently ignore the risks of hypocholesterolemia, such as in this study. Beyond the diabetes signal identified here, very low LDL (<70 mg/dL) has been consistently linked […]
Comment: It’s Thanksgiving, and I figured it would be fun to see if there was any actual research on turkey and sleepiness. There isn’t, but I came across this interesting study showing that tryptophan is associated with both improved sleep and decreased depression symptoms. Despite it’s reputation, turkey is actually about equivalent in tryptophan to […]
📝Comment: This meta-analysis represents the highest level of evidence for a prognostic biomarker, using Individual-Participant-Data (IPD) analysis across 15 high-quality prospective cohorts. While the absolute increase in risk prediction (C-index) is modest, high-sensitivity troponins are an independent prognostic factor for cardiovascular disease that provide greater predictive gains than traditional inflammatory markers like C-reactive protein (CRP), […]
Comment: Although we are all used to seeing troponin used to rule in or out a heart attack, this study shows it can be used for prognostic chronic risk stratification. It shows there is a population of older, asymptomatic people who, despite having no history of MI or overt CVD, are walking around with a […]
Comment: A more recent study, this one was in women and showed that nuts and this time seeds are perfectly safe for diverticulitis. Corn actually decreased the risk. Summary: 🎯 Clinical Bottom Line This large prospective cohort study provides compelling evidence to refute the historical dogma that women should avoid “particulate” foods—specifically nuts, seeds, corn, […]
Comment: Not only do nuts not increase incidence, but they actually decrease the incidence. Another example of ‘logical’ thinking that was wrong on testing, but still endures. One of my favorite quotes ever, from the lead researcher, in that it underlines so much of medical thinking:“It is not exactly clear where this idea came from […]
Comment: I don’t usually review abstracts, but I think this is interesting enough that it’s worth posting at the very least to mark the dosing strategy, which finally mimics what we do clinically. The most compelling takeaway from the TARGET-D trial isn’t just the reduction in recurrent Myocardial Infarction (MI), but how they achieved it: through […]
Comment: This massive Swedish cohort study serves as a critical update for anyone managing contraception. While the absolute risk remains low—approximately 1 extra case per 7,752 users per year—the relative increase in breast cancer risk is substantial, driven largely by specific hormonal components. The overall Hazard Ratio of 1.24 suggests a 24% increase in relative […]
Comment: It’s not like using B12 is a shocking new concept – it’s commonly used for brain and memory issues. This study adds that measuring serum B12 alone isn’t sufficient. The protective association was driven by the composite score, not standard cobalamin levels. To truly ensure our patients are utilizing B12 for neuroprotection, we must […]
